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Spironolactone is commonly used in the treatment of hirsutism in women, and is considered to be a first-line antiandrogen for this indication. [67] Spironolactone can be used in the treatment of female-pattern hair loss (pattern scalp hair loss in women). [68] There is tentative low quality evidence supporting its use for this indication. [69]
Androgen-dependent skin and hair conditions like acne and pattern hair loss may also occur in hyperandrogenism, and menstrual disturbances, like amenorrhea, are commonly seen. [13] Although antiandrogens do not treat the underlying cause of hyperandrogenism (e.g., PCOS), they are able to prevent and reverse its manifestation and effects. [ 13 ]
Spironolactone is a once-a-day tablet that can stop hair loss from progressing and encourage new hair growth. It’s especially useful for women with hormonal issues like PCOS. It may take six to ...
The AR antagonism of spironolactone mostly underlies its antiandrogenic activity and is the major mechanism responsible for its therapeutic benefits in the treatment of androgen-dependent conditions like acne, hirsutism, and pattern hair loss and its usefulness in hormone therapy for transgender women.
For those with signs of hyperandrogenism (excessive androgen hormones) and other hormonal imbalances, spironolactone may be an effective treatment for female pattern hair loss. Spironolactone ...
In some cases, other medications like spironolactone may be prescribed off-label for hair loss. This is typically only used in women and not in men, because in men it can lead to gynecomastia ...
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