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C2C12 cells demonstrate rapid development and maturation into functional skeletal muscle cells or cardiac muscle cells, having the ability to contract and generate force. [6] The rate of muscle formation from C2C12 cells can be controlled by the introduction of loss-of-functions genes vital for the fusion of myoblasts and myogenesis. [7]
The expression of cTnT in skeletal tissue of patients with chronic skeletal muscle injuries has been described. [12] Inside the cardiac troponin complex the strongest interaction between molecules has been demonstrated for cTnI – TnC binary complex especially in the presence of Ca 2+ ( KA = 1.5 × 10 −8 M −1). [13]
Firstly, it binds to the intracellular side of the DHPR, signalling the channels to close and preventing further influx of Ca 2+ into the cell. Secondly Ca 2+ indirectly activates proteins, called myofilaments, resulting in muscle contraction. The two main myofilaments in cardiac (and skeletal) muscle are actin and myosin.
T-tubules (transverse tubules) are extensions of the cell membrane that penetrate into the center of skeletal and cardiac muscle cells.With membranes that contain large concentrations of ion channels, transporters, and pumps, T-tubules permit rapid transmission of the action potential into the cell, and also play an important role in regulating cellular calcium concentration.
Depiction of smooth muscle contraction. Muscle contraction is the activation of tension-generating sites within muscle cells. [1] [2] In physiology, muscle contraction does not necessarily mean muscle shortening because muscle tension can be produced without changes in muscle length, such as when holding something heavy in the same position. [1]
In vitro muscle testing can be done on any scale of muscle organization - entire groups of muscles (provided they share a common insertion or origin, as in the human quadriceps), a single muscle, a "bundle" of muscle fibers, a single muscle fiber, a single myofibril, a single sarcomere, a cardiomyocyte or even a half-sarcomere. Muscle fibers ...
These studies have been extended to a number of cell types with similar results. Extensive studies in neuronal cells, [21] fibroblasts, [16] [17] [22] skeletal muscle [23] [24] and osteoclast cells has further highlighted the complex association tropomyosin isoforms have with cellular structures. These studies have led to the realization that ...
A myokine is one of several hundred cytokines or other small proteins (~5–20 kDa) and proteoglycan peptides that are produced and released by skeletal muscle cells (muscle fibers) in response to muscular contractions. [1] They have autocrine, paracrine and/or endocrine effects; [2] their systemic effects occur at picomolar concentrations. [3] [4]