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Dexmedetomidine is a highly selective α 2-adrenergic receptor agonist. It possesses an α 2:α 1 selectivity ratio of 1620:1, making it 8 times more selective for the α 2-adrenergic receptor than the related drug clonidine.
Atipamezole, sold under the brand name Antisedan among others, is a synthetic α 2 adrenergic receptor antagonist used for the reversal of the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. Its reversal effect works by competing with the sedative for α 2-adrenergic receptors and displacing them.
Medetomidine is a racemic mixture of two optical or stereoisomers, levomedetomidine and dexmedetomidine. [4] The latter causes the alpha 2- adrenergic agonist effects. [5] It is often used as the hydrochloride salt, medetomidine hydrochloride, a crystalline white solid that can be administered as an intravenous drug solution with sterile water.
England’s national dish is popular in microwave form in good ole’ Kentucky. Wilder Shaw / Cheapism. Louisiana. Butter Chicken with Basmati Rice .
The claim: Lindsey Graham announced he wouldn’t confirm Matt Gaetz as attorney general. A Nov. 13 Facebook post (direct link, archive link) includes photos of South Carolina Sen. Lindsey Graham ...
Spirit Airlines said Monday it has filed for Chapter 11 bankruptcy protection after struggling with losses, growing debt and a failed merger during the post-pandemic travel lull.
Dexmedetomidine has the trade name of Dexdomitor. It is frequently used in dogs and cats both for sedation or as a pre-anesthetic. It is licensed for use in the United states by Pfizer Animal Health. In my experience, it is rarely used as a single agent. It has potent synergistic characteristics when used with an opiod.
The following list of cat breeds includes only domestic cat breeds and domestic and wild hybrids. The list includes established breeds recognized by various cat registries , new and experimental breeds, landraces being established as standardized breeds, distinct domestic populations not being actively developed and lapsed (extinct) breeds.