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  2. Neurotrophic hypothesis of depression - Wikipedia

    en.wikipedia.org/wiki/Neurotrophic_hypothesis_of...

    The neurotrophic hypothesis of depression [1] proposes that major depressive disorder (MDD) is caused, at least partly, by impaired neurotrophic support.Neurotrophic factors (also known as neurotrophins) are a family of closely related proteins which regulate the survival, development, and function of neurons in both the central and peripheral nervous systems.

  3. Biology of depression - Wikipedia

    en.wikipedia.org/wiki/Biology_of_depression

    The serotonin "chemical imbalance" theory of depression, proposed in the 1960s, [35] is not supported by the available scientific evidence. [ 35 ] [ 36 ] SSRIs alter the balance of serotonin inside and outside of neurons: their clinical antidepressant effect (which is robust in severe depression [ 37 ] ) is likely due to more complex changes in ...

  4. Serotonin–norepinephrine–dopamine reuptake inhibitor

    en.wikipedia.org/wiki/Serotonin–norepinephrine...

    Shortly after Schildkraut's catecholamine hypothesis was published, Coppen proposed that 5-HT, rather than NA, was the more important neurotransmitter in depression. This was based on similar evidence to that which produced the NA theory as reserpine, imipramine, and iproniazid affect the 5-HT system, in addition to the noradrenergic system.

  5. Neurogenesis hypothesis of depression - Wikipedia

    en.wikipedia.org/wiki/Neurogenesis_hypothesis_of...

    While depression is a complex condition with many factors involved, it is commonly attributed to an imbalance of several key monoamine neurotransmitters, including serotonin, dopamine and norepinephrine. This monoamine hypothesis of depression is popular because of the simplicity of the explanation. [4]

  6. Serotonin - Wikipedia

    en.wikipedia.org/wiki/Serotonin

    Serotonin (/ ˌ s ɛr ə ˈ t oʊ n ɪ n, ˌ s ɪər ə-/) [6] [7] [8] or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter.Its biological function is complex, touching on diverse functions including mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vasoconstriction.

  7. Scientists Say This Natural Remedy May Help Those With Depression

    www.aol.com/scientists-natural-remedy-may-help...

    Major depressive disorder impacts approximately 5% of adults around the world.And while doctors commonly prescribe antidepressants to people struggling with depression, they aren’t for everyone ...

  8. Behavioral theories of depression - Wikipedia

    en.wikipedia.org/wiki/Behavioral_theories_of...

    Three alternative therapies emerged over the next 4 years: Lewinsohn's social learning theory, Patterson's anti-depression milieu, and Lazarus' behavioral deprivation. Social learning theory focused on identifying and avoiding behaviors that increased depressive thoughts. Anti-depression milieu encouraged catharsis to overcome depression.

  9. Long-term depression - Wikipedia

    en.wikipedia.org/wiki/Long-term_depression

    In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the CNS with varying mechanisms depending upon brain region and developmental progress.

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