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Use of antidepressants during pregnancy may result in fetus abnormalities affecting functional development of the brain and behavior. [89] Studies have shown correlations between pregnant women treated with SNRIs and risk of hypertensive disorders, [90] preeclampsia, [91] miscarriage, [92] seizures in children, [93] and many other adverse affects.
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
Enoxaparin is listed as Pregnancy Category B, meaning animal studies have failed to show harmful effects to the fetus and therefore are safe to use in pregnant women. [ 37 ] [ 39 ] However, pregnant women taking LMWH may not experience the full anticoagulant effect due to the nature of the medication compared to other anticoagulants (i.e ...
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Nortriptyline may cause problems if taken during pregnancy. [8] Use during breastfeeding appears to be relatively safe. [7] It is a tricyclic antidepressant (TCA) and is believed to work by altering levels of serotonin and norepinephrine. [8] Nortriptyline was approved for medical use in the United States in 1964. [8]
This side effect has been particularly associated with serotonergic antidepressants like SSRIs and SNRIs, but may be less with atypical antidepressants like bupropion, agomelatine, and vortioxetine. [ 77 ] [ 79 ] [ 80 ] Higher doses of antidepressants seem to be more likely to produce emotional blunting than lower doses. [ 77 ]
Antidepressant exposure is not associated with an increased risk of spontaneous abortion. [55] There is a tentative association of SSRI use during pregnancy with heart problems in the baby. [ 56 ] The advantages of their use during pregnancy may thus not outweigh the possible negative effects on the baby.
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