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1α-Hydroxyvitamin D 5 is a chemical derivative of vitamin D 5.The motive to study 1α-hydroxyvitamin D 5 as a potential pharmaceutical drug stemmed from the tendency of calcitriol, a natural metabolite produced in the kidney, to cause toxic hypercalcemia in patients when dosed at concentrations needed to interrupt prostate cancer cells' cycle and stimulate apoptosis.
While serum low 25-hydroxyvitamin D status has been associated with a higher risk of cancer in observational studies, [101] [102] [103] the general conclusion is that there is insufficient evidence for an effect of vitamin D supplementation on the risk of cancer, [2] [104] [105] although there is some evidence for reduction in cancer mortality ...
These two forms of vitamin D are metabolized in the liver and stored as 25-hydroxyvitamin D. [4] Before biological use, the storage form must be converted into an active form. One common active form is 1,25-dihydroxyvitamin D. [4] The term vitamin D in this article means cholecalciferol, ergocalciferol, 25-hydroxyvitamin D, and the active forms ...
25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase [5] or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene.
Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body. [ 1 ] [ 7 ] [ 2 ] One nanogram per millilitre ( 1 ng/mL ) is equivalent to 2.5 nanomoles per litre ( 2.5 nmol/L ).
Decamethylcyclopentasiloxane, also known as D 5 and D5, is an organosilicon compound with the formula [(CH 3) 2 SiO] 5. It is a colorless and odorless liquid that is slightly volatile . [ 5 ]
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It is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D (25(OH)D) in plasma, which is the most accurate measure of stores of vitamin D in the body. Deficiency is defined as less than 10 ng/mL, and insufficiency in the range of 10–30 ng/mL.
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