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The effects of transforming growth factor-β (TGF-β) are determined by cellular context. There are three kinds of contextual factors that determine the shape the TGF-β response: the signal transduction components, the transcriptional cofactors and the epigenetic state of the cell. The different ligands and receptors of TGF-β are significant ...
This means the upstream and downstream areas of the molecule may change depending on which gene is used as the reference. The terms upstream and downstream are sometimes also applied to a polypeptide sequence, where upstream refers to a region N-terminal and downstream to residues C-terminal of a reference point.
The downstream effects of these signaling pathways may include additional enzymatic activities such as proteolytic cleavage, phosphorylation, methylation, and ubiquitinylation. Signaling molecules can be synthesized from various biosynthetic pathways and released through passive or active transports, or even from cell damage.
Upstream and downstream can refer to: Molecular biology. Upstream and downstream (DNA), determining relative positions on DNA;
Downstream may refer to: Downstream (hydrology) , the direction towards the mouth of a stream, i.e. the direction the current flows Downstream (bioprocess) , when a cell mass from an upstream process (isolated, grown and harvested) is further processed to meet purity and quality requirements
The PI3K-Akt pathway has many downstream effects and must be carefully regulated. One of the ways the pathway is negatively regulated is by reducing PIP 3 levels. Phosphatase and tensin homolog (PTEN) antagonises PI3K by converting PI(3,4,5)P 3 into PI(4,5)P 2.
Pharmacodynamics (PD) is the study of the biochemical and physiologic effects of drugs (especially pharmaceutical drugs). The effects can include those manifested within animals (including humans), microorganisms, or combinations of organisms (for example, infection).
The moving fluid creates a space devoid of downstream-flowing fluid on the downstream side of the object. Fluid behind the obstacle flows into the void creating a swirl of fluid on each edge of the obstacle, followed by a short reverse flow of fluid behind the obstacle flowing upstream, toward the back of the obstacle.