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People received M (9 mg/m2 ) plus prednisone (60 mg/m2 ) daily for four days every 6 weeks or the same MP schedule with bortezomib, 1.3 mg/m2 iv on days 1, 8, 11, 22, 25, 29, and 32 of every 6 week cycle for 4 cycles then once weekly for 4 weeks for 5 cycles. [24] Time- to- progression (TTP) was the primary efficacy endpoint. [24]
It can be taken by mouth, injected into a vein, used topically as a skin cream, or as eye drops. [7] [8] [6] It differs from the similarly named prednisone in having a hydroxyl at the 11th carbon instead of a ketone. Common side effects with short-term use include nausea, difficulty concentrating, insomnia, increased appetite, and fatigue. [5]
Prednisone is a prodrug and must be converted to prednisolone by the liver before it becomes active. [6] [7] Prednisolone then binds to glucocorticoid receptors, activating them and triggering changes in gene expression. [4] Prednisone was patented in 1954 and approved for medical use in the United States in 1955.
"Eat It" is a 1984 song by American comedy music artist "Weird Al" Yankovic. It is a parody of Michael Jackson 's 1983 single " Beat It ", with the contents changed to be about an exasperated parent attempting to get their picky child to eat anything at all, much less to eat properly.
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"Dance" is a song by American heavy metal band Ratt. It is the first track off their 1986 album Dancing Undercover and the tenth track of their compilation album Ratt & Roll 81-91. It reached #59 on the Billboard Hot 100. The song was written by Stephen Pearcy, guitarists Robbin Crosby and Warren DeMartini, and album producer Beau Hill.
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The official music video for the song was released on 27 January 2017, through Ultra Music and Martin Jensen's YouTube account. It was directed by Nicolas Tobias Følsgaard and choreographed by Tobias Ellehammer and stars dancers such as Haeni Kim, Dylan Mayoral, Jamie Telford, Sandra Brünnich, Lianne Lee May, Michel Patric Sian, Remi Black and Cilia Trappaud, who dance throughout the whole ...