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Airway remodelling is a multifaceted process involving multiple airway tissues. These include goblet cell hyperplasia, leading to increased mucus production, and airway smooth muscle hypertrophy (or smooth muscle cell hyperplasia), leading to the release of pro-inflammatory and pro-fibrotic messengers contributing to subepithelial fibrosis.
Asthma is a common long-term inflammatory disease of the airways of the lungs. [4] Asthma occurs when allergens, pollen, dust, or other particles, are inhaled into the lungs, causing the bronchioles to constrict and produce mucus, which then restricts oxygen flow to the alveoli.
Illustration depicting bronchoconstriction (Asthma) Bronchoconstriction is the constriction of the airways in the lungs due to the tightening of surrounding smooth muscle , with consequent coughing , wheezing , and shortness of breath .
“They have smaller caliber airways so irritation and swelling manifest with problems earlier.” (Adults with asthma, chronic obstructive pulmonary disease and heart disease are also at risk of ...
Asthma can cause wheezing, breathlessness, a tight chest and coughing. For some people asthma can be mild, for others it is more severe. Sometimes the condition can cause a person to have an ...
Asthma attacks, which occur when the sides of the airways in the lungs swell and the airways shrink, typically happen when something bothers the lungs. And, severe asthma attacks can be life ...
The airways narrow and produce excess mucus, making it difficult to breathe. In essence, asthma is the result of an immune response in the bronchial airways. [3] The airways of asthma patients are "hypersensitive" to certain triggers, also known as stimuli (see below).
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