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In genetics, the coefficient of coincidence (c.o.c.) is a measure of interference in the formation of chromosomal crossovers during meiosis. It is generally the case that, if there is a crossover at one spot on a chromosome, this decreases the likelihood of a crossover in a nearby spot. [1] This is called interference.
Alipogene tiparvovec (Glybera): AAV-based treatment for lipoprotein lipase deficiency (no longer commercially available); Axicabtagene ciloleucel (Yescarta): treatment for large B-cell lymphoma [1]
Drug Manufacturer Indication Tezacaftor/ivacaftor [2] Vertex Pharmaceuticals: cystic fibrosis: Durvalumab [2] AstraZeneca UK: unresectable Stage III non-small cell lung cancer: Ibalizumab-uiyk [2] Theratechnologies: human immunodeficiency virus type 1 (HIV-1) infection Brentuximab vedotin [2] Seattle Genetics: Hodgkin lymphoma: Ipilimumab [2 ...
(Reuters) -The U.S. Food and Drug Administration has approved Ionis Pharmaceuticals' drug to treat a rare genetic disorder, making it the company's first wholly-owned drug, the health regulator's ...
Acne is not caused by a lack of hygiene or eating fatty foods, though certain medication or a carbohydrate-rich diet may worsen it. [407] Dandruff is not caused by poor hygiene, though infrequent hair-washing can make it more obvious. The exact causes of dandruff are uncertain, but they are believed to be mostly genetic and environmental ...
Crossover interference is the term used to refer to the non-random placement of crossovers with respect to each other during meiosis.The term is attributed to Hermann Joseph Muller, who observed that one crossover "interferes with the coincident occurrence of another crossing over in the same pair of chromosomes, and I have accordingly termed this phenomenon ‘interference’."
Containing 1170 drugs with more than 3800 interactions, and approximately 2000 known SNPs. These SNPs are listed and ordered according to their effect on expression and/or activity. [79] PharmGKB: The Pharmacogenomics Knowledge Base (PharmGKB) is an interactive tool for researchers investigating how genetic variation affects drug response. [80]
Luck. Fate. Blessing. A glitch in the matrix. Or, if you’re more skeptical, just a coincidence.. It’s a phenomenon that, from a statistical perspective, is random and meaningless.