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Persister cells are subpopulations of cells that resist treatment, and become antimicrobial tolerant by changing to a state of dormancy or quiescence. [1] [2] Persister cells in their dormancy do not divide. [3] The tolerance shown in persister cells differs from antimicrobial resistance in that the tolerance is not inherited and is reversible. [4]
The systems of the body most affected by chemotherapy drugs include visual and semantic memory, attention and motor coordination and executive functioning. [9] [10] These effects can impair a chemotherapy patient's ability to understand and make decisions regarding treatment, perform in school or employment and can reduce quality of life. [10]
The cancer stem cell model, also known as the Hierarchical Model proposes that tumors are hierarchically organized (CSCs lying at the apex [6] (Fig. 3).) Within the cancer population of the tumors there are cancer stem cells (CSC) that are tumorigenic cells and are biologically distinct from other subpopulations [7] They have two defining features: their long-term ability to self-renew and ...
This occurs most commonly after the treatment of lymphomas and leukemias and in particular when treating non-Hodgkin lymphoma, acute myeloid leukemia, and acute lymphoblastic leukemia. [ 2 ] [ 3 ] This is a potentially fatal complication and people at an increased risk for TLS should be closely monitored while receiving chemotherapy and should ...
Natural transformation is a process of DNA transfer between cells, and is regarded as a form of bacterial sexual interaction. In the fruit fly Drosophila melanogaster , exposure to mitomycin C increases recombination during meiosis, a key stage of the sexual cycle. [ 5 ]
She explained that chemotherapy is a “powerful tool” and that, while it can have “challenging side effects, treatments and supportive care have come a long way. Doctors can often manage or ...
At Memorial Sloan Kettering Cancer Center in NYC, ready for my second round of chemotherapy. I had only four glorious days with my bob before starting chemo. But even three weeks in, I still had ...
In one of the country's most "embarrassing" cases, German police spent years tracking down a killer only to turn the investigation back on themselves