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Rh disease (also known as rhesus isoimmunization, Rh (D) disease, or rhesus incompatibility, and blue baby disease) is a type of hemolytic disease of the fetus and newborn (HDFN). HDFN due to anti-D antibodies is the proper and currently used name for this disease as the Rh blood group system actually has more than 50 antigens and not only the ...
Rh factor testing is crucial to prevent haemolytic conditions caused by the Rh incompatibility. [citation needed] The consequence of having haemolytic conditions can be dangerous or even lethal as it may lead to multiple complications. Not only does Rh factor testing determine the rhesus status of the individuals, but also indicate the ...
The expression of ABO blood group antigens is determined by the interaction of three genes: the ABO gene, which controls expression of the A and B antigens; the FUT1 or H gene, which controls expression of the H antigen, the precursor of ABO antigens; and the secretor gene, FUT2 or Se.
If the father is heterozygous, there is a 50% chance that the fetus will be RhD positive, as he will randomly pass on either the RhD positive allele or not. [9]: 130 . Not all Rh-negative patients are capable of being immunized to the RhD antigen, and mothers may only become immunized after many repeated pregnancies.
The terms atherosclerosis and arteriosclerosis sound similar but are slightly different in meaning. Atherosclerosis is a type of arteriosclerosis. It refers to the build-up of plaque in blood vessels.
To avoid transfusion reactions, the donor and recipient blood are tested, typically ordered as a "type and screen" for the recipient. The "type" in this case is the ABO and Rh type, specifically the phenotype, and the "screen" refers to testing for atypical antibodies that might cause transfusion problems. The typing and screening are also ...
Cell-free DNA can be used the determine the Rh antigen of the fetus when the mother is Rh negative. Blood is taken from the mother during the pregnancy, and using PCR, can detect the K, C, c, D, and E alleles of fetal DNA. This blood test is non-invasive to the fetus and is an easy way of checking antigen status and risk of HDN.
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