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2. Xanthine oxidase inhibitor - Wikipedia

   en.wikipedia.org/wiki/Xanthine_oxidase_inhibitor

   A xanthine oxidase inhibitor is any substance that inhibits the activity of xanthine oxidase, an enzyme involved in purine metabolism.In humans, inhibition of xanthine oxidase reduces the production of uric acid, and several medications that inhibit xanthine oxidase are indicated for treatment of hyperuricemia and related medical conditions including gout. [1]

3. Probenecid - Wikipedia

   en.wikipedia.org/wiki/Probenecid

   Probenecid, also sold under the brand name Probalan, is a medication that increases uric acid excretion in the urine. It is primarily used in treating gout and hyperuricemia . Probenecid was developed as an alternative to caronamide [ 1 ] to competitively inhibit renal excretion of some drugs, thereby increasing their plasma concentration and ...

4. Uricosuric - Wikipedia

   en.wikipedia.org/wiki/Uricosuric

   By decreasing plasma uric acid levels, help dissolve these crystals, while limiting the formation of new ones. However, the increased uric acid levels in urine can contribute to kidney stones . Thus, use of these drugs is contraindicated in persons already with a high urine concentration of uric acid ( hyperuricosuria ).

5. Allopurinol - Wikipedia

   en.wikipedia.org/wiki/Allopurinol

   Allopurinol is used to reduce urate formation in conditions where urate deposition has already occurred or is predictable. The specific diseases and conditions where it is used include gouty arthritis, skin tophi, kidney stones, idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate ...

6. Gout - Wikipedia

   en.wikipedia.org/wiki/Gout

   [20] [64] Probenecid may be used if undersecretion of uric acid is present (24-hour urine uric acid less than 800 mg). [75] It is, however, not recommended if a person has a history of kidney stones. [75] Probenecid can be used in a combined therapy with allopurinol is more effective than allopurinol monotherapy. [76] [77] [78]

7. Ocasio-Cortez loses bid to be top Democrat on House ... - AOL

   www.aol.com/ocasio-cortez-loses-bid-top...

   House Democratic veteran Rep. Gerry Connolly fended off a challenge from progressive Rep. Alexandria Ocasio-Cortez on Tuesday, putting the Virginia Democrat in line to become the House Oversight ...