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As per Falkow's original descriptions, the three postulates are: [1] "The phenotype or property under investigation should be associated with pathogenic members of a genus or pathogenic strains of a species. Specific inactivation of the gene(s) associated with the suspected virulence trait should lead to a measurable loss in pathogenicity or ...
Falkow is known as the father of the field of molecular microbial pathogenesis. [1] He formulated molecular Koch's postulates, which have guided the study of the microbial determinants of infectious diseases since the late 1980s. [2] Falkow spent over 50 years uncovering molecular mechanisms of how bacteria cause disease and how to disarm them. [1]
In 1988, microbiologist Stanley Falkow developed a set of three Molecular Koch's postulates for identifying the microbial genes encoding virulence factors. First, the phenotype of a disease symptom must be associated with a specific genotype only found in pathogenic strains. Second, that symptom should not be present when the associated gene is ...
Microbial pathogenesis is a field of microbiology that started at least as early as 1988, with the identification of the triune Falkow's criteria, aka molecular Koch's postulates.
Stanley Falkow (1934–2018), US microbial geneticist, molecular mechanisms of bacterial pathogenesis; Harold Falls (1909–2006), US ophthalmologic geneticist, helped found first genetics clinic in US; William C. Farabee (1865–1925), US anthropologist, brachydactyly is evidence of Mendelism in humans
2011 - Stadtman Distinguished Scientist Award, American Society for Biochemistry and Molecular Biology [7] 2007 - Builders of Science Award, Research!America [8] 2005 - Woodrow Wilson Award for Public Service [9] 2005 - Herbert Tabor Award, American Society for Biochemistry and Molecular Biology [10] 2003 - Albany Medical Center Prize [11]
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Frank Henry Westheimer (January 15, 1912 – April 14, 2007) was an American chemist.He taught at the University of Chicago from 1936 to 1954, and at Harvard University from 1953 to 1983, becoming the Morris Loeb Professor of Chemistry in 1960, and Professor Emeritus in 1983. [2]