Search results
Results from the WOW.Com Content Network
PFK belongs to the phosphofructokinase B (PfkB) family of sugar kinases. [7] Other members of this family (also known as the Ribokinase family) include ribokinase (RK), adenosine kinase (AK), inosine kinase, and 1-phosphofructokinase. [7] [8] [9] The members of the PfkB/RK family are identified by the presence of three conserved sequence motifs.
The lack of PFK blocks the completion of the glycolytic pathway. Therefore, all products past the block would be deficient, including Adenosine triphosphate (ATP). It may affect humans as well as other mammals (especially dogs). [4] It was named after the Japanese physician Seiichiro Tarui (b. 1927), who first observed the condition in 1965. [5]
Phosphofructokinase-1 (PFK-1) is one of the most important regulatory enzymes (EC 2.7.1.11) of glycolysis. It is an allosteric enzyme made of 4 subunits and controlled by many activators and inhibitors .
PFK-2 is known as the "bifunctional enzyme" because of its notable structure: though both are located on one protein homodimer, its two domains act as independently functioning enzymes. [5] One terminus serves as a kinase domain (for PFK-2) while the other terminus acts as a phosphatase domain (FBPase-2). [6]
A futile cycle, also known as a substrate cycle, occurs when two metabolic pathways run simultaneously in opposite directions and have no overall effect other than to dissipate energy in the form of heat. [1] The reason this cycle was called "futile" cycle was because it appeared that this cycle operated with no net utility for the organism.
Simply put, dogs jump up to say hello or to get attention. It's one thing if your 10-pound Shih-Tzu jumps up, but it's another thing if your 100-pound Mastiff does it.
Kizik makes some of the best shoes our editors have tested for those who have arthritic feet.The Kizik Athens are easy to slide into and have the love of more than 2,500 reviewers. And during ...
The upstream signaling pathway is triggered by the binding of a signaling molecule, a ligand, to a receiving molecule, a receptor. Receptors and ligands exist in many different forms, and only recognize/bond to particular molecules. Upstream extracellular signaling transduce a variety of intracellular cascades. [1]