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Thalidomide, sold under the brand names Contergan and Thalomid among others, is an oral medication used to treat a number of cancers (e.g., multiple myeloma), graft-versus-host disease, and many skin disorders (e.g., complications of leprosy such as skin lesions).
Feet of a baby born to a mother who had taken thalidomide while pregnant. In the late 1950s and early 1960s, the use of thalidomide in 46 countries was prescribed to women who were pregnant or who subsequently became pregnant, and consequently resulted in the "biggest anthropogenic medical disaster ever," with more than 10,000 children born with a range of severe deformities, such as ...
Jacob Sheskin, sometimes written as Sheskin Jacob (Hebrew: יעקב שסקין; 1914 – April 17, 1999) was a Russian-born Israeli physician best known for his 1964 serendipitous discovery that thalidomide can be used as a treatment for leprosy at Hadassah University in Jerusalem. [1]
Morhan was established on June 6, 1981, by eight people in São Paulo, Brazil, whom had met through extensive research on leprosy or having lived in centers for people afflicted with leprosy. [1] Morhan first emerged as an organization for the physically handicapped in general, although a specific group for those disabled by Hansen’s disease ...
Grünenthal provided thalidomide to more than 1,000 patients with leprosy in the United States until a few months before July, 1986. The drug is especially helpful to patients with leprosy in treating an extremely painful allergic reaction of the skin. The company discontinued exporting thalidomide because of liability fears.
A leprostatic agent is a drug that interferes with proliferation of the bacterium that causes leprosy. [1] [2] The following agents are leprostatic agents: [3] acedapsone; clofazimine; dapsone; desoxyfructo-serotonin; diucifon; ethionamide; rifampicin; rifapentine; sulfameter; thalidomide; Leprosy is a chronic infectious disease caused by ...
Rea and his colleague Robert Modlin researched the role the immune system played in symptoms of leprosy, which led to the development of new treatments for the disease that rendered it non-contagious and allowed leprosy patients to live normal lives. [2] Rea also supported the use of thalidomide to treat a complication of leprosy. [2]
Thalidomide: 1961 Germany Withdrawn because of risk of teratogenicity; [62] returned to market for use in leprosy and multiple myeloma under FDA orphan drug rules Thenalidine: 1963 Canada, UK, US Neutropenia [3] [63] Thiobutabarbitone: 1993 Germany Kidney injury. [3] Thioridazine (Melleril) 2005 Germany, UK