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  2. Phosphofructokinase 2 - Wikipedia

    en.wikipedia.org/wiki/Phosphofructokinase_2

    Furthermore, the allosteric regulation of PFK2 is very similar to the regulation of PFK1. [20] High levels of AMP or phosphate group signifies a low energy charge state and thus stimulates PFK2. On the other hand, a high concentration of phosphoenolpyruvate (PEP) and citrate signifies that there is a high level of biosynthetic precursor and ...

  3. Phosphofructokinase - Wikipedia

    en.wikipedia.org/wiki/Phosphofructokinase

    PFK exists as a homotetramer in bacteria and mammals (where each monomer possesses 2 similar domains) and as an octomer in yeast (where there are 4 alpha- (PFK1) and 4 beta-chains (PFK2), the latter, like the mammalian monomers, possessing 2 similar domains [3]). This protein may use the morpheein model of allosteric regulation. [5]

  4. Allosteric regulation - Wikipedia

    en.wikipedia.org/wiki/Allosteric_regulation

    Allosteric regulation of an enzyme. In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.

  5. Enzyme activator - Wikipedia

    en.wikipedia.org/wiki/Enzyme_activator

    These molecules are often involved in the allosteric regulation of enzymes in the control of metabolism. In some cases, when a substrate binds to one catalytic subunit of an enzyme, this can trigger an increase in the substrate affinity as well as catalytic activity in the enzyme's other subunits, and thus the substrate acts as an activator.

  6. Journal pulls scientific paper that popularized ... - AOL

    www.aol.com/journal-pulls-scientific-paper...

    One of the most notable scientific papers that first popularized hydroxychloroquine as a COVID-19 treatment was retracted from its journal due to ethical and methodological issues. Retractions in ...

  7. New COVID-19 test provides accurate results within 4 ... - AOL

    www.aol.com/news/covid-19-test-provides-accurate...

    China, where COVID-19 was first detected, is currently one of the world’s biggest manufacturers of coronavirus test kits. Customs data show that the country exported $1.6 billion worth of such ...

  8. Fructose 2,6-bisphosphate - Wikipedia

    en.wikipedia.org/wiki/Fructose_2,6-bisphosphate

    Fru-2,6-P 2 strongly activates glucose breakdown in glycolysis through allosteric modulation (activation) of phosphofructokinase 1 (PFK-1).Elevated expression of Fru-2,6-P 2 levels in the liver allosterically activates phosphofructokinase 1 by increasing the enzyme’s affinity for fructose 6-phosphate, while decreasing its affinity for inhibitory ATP and citrate.

  9. 3 Dividend-Paying Value Stocks to Buy Even If There's a Stock ...

    www.aol.com/3-dividend-paying-value-stocks...

    Image source: Getty Images. 1. Lockheed Martin. After its stock price reached an all-time high earlier this year, Lockheed Martin and its defense contractor peers have sold off considerably over ...