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Indirect DNA damage occurs when a UV-photon is absorbed in the human skin by a chromophore that does not have the ability to convert the energy into harmless heat very quickly. [2] Molecules that do not have this ability have a long-lived excited state.
“UV exposure wreaks havoc on the skin by generating free radicals that produce inflammation and damage cell function and your skin’s DNA. This DNA damage can cause changes in your genes called ...
This process of absorption works to reduce the risk of DNA damage and the formation of pyrimidine dimers. UVA light makes up 95% of the UV light that reaches earth, whereas UVB light makes up only about 5%. UVB light is the form of UV light that is responsible for tanning and burning. Sunscreens work to protect from both UVA and UVB rays.
All bands of UV radiation damage collagen fibers and accelerate aging of the skin. Both UVA and UVB destroy vitamin A in skin, which may cause further damage. [61] UVB radiation can cause direct DNA damage. [62] This cancer connection is one reason for concern about ozone depletion and the ozone hole.
“Skin cancer is caused by exposing the cells in the skin to UV radiation, and particularly UVB radiation,” researcher Dr. Rachel Neale told CNN Medical Correspondent Meg Tirrell recently in a ...
The sun is, by far, the greatest source of ultraviolet (UV) radiation, which is the culprit that causes most skin cancers—the most common form of cancer in the U.S. According to the Skin Cancer ...
It has been reported that UV radiation leads to local and systemic immunosuppression, due to DNA damage and altered cytokine expression. This has implications in cutaneous tumor surveillance. The Langerhans cells may undergo changes in quantity, morphology, and function due to UV exposure and may eventually become depleted. One proposed ...
According to the National Toxicology Program Report on Carcinogens from the US Department of Health and Human Services, broad-spectrum UV radiation is a carcinogen whose DNA damage is thought to contribute to most of the estimated 1.5 million skin cancers and the 8,000 deaths due to metastatic melanoma that occur annually in the United States.