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In dogs, the minimum lethal dose of THC is over 3000 mg/kg. [20] According to The Merck Index, [21] the LD 50 of THC (the dose which causes the death of 50% of individuals) is 1270 mg/kg for male rats and 730 mg/kg for female rats from oral consumption in sesame oil, and 42 mg/kg for rats from inhalation. [22]
Over time, the marijuana gateway hypothesis has been studied more and more. In one published study, the use of marijuana was shown not a reliable gateway cause of illicit drug use. [67] However, social factors and environment influence drug use and abuse, making the gateway effects of cannabis different for those in differing social circumstances.
A 2011 review considered cannabis to be generally safe, [33] and it appears safer than opioids in palliative care. [34] A 2022 review concluded the pain relief experienced after using medical cannabis is due to the placebo effect, especially given widespread media attention that sets the expectation for pain relief. [35]
In clinical trials, one to three percent of men who used Cialis reported leg pain and, on occasion, pain in their other limbs. This side effect was most common in guys who took 10 to 20 milligrams ...
Many health conditions can cause joint pain as a symptom. These include: ... A 2019 study found that sustained weight loss of 10 to 20 percent of baseline body weight had substantial benefits for ...
A 2013 review estimates daily use is associated with a 10–20% rate of dependence. [12] The highest risk of cannabis dependence is found in those with a history of poor academic achievement, deviant behavior in childhood and adolescence, rebelliousness, poor parental relationships, or a parental history of drug and alcohol problems. [ 83 ]
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Using a more sensitive cutoff of 20 ng/mL (less common but still used by some labs), the most likely maximum times are 7 days and 21 days, respectively. In extraordinary circumstances of extended marijuana use, detection times of more than 30 days are possible in some individuals at the 20 ng/mL cutoff. [7]