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  2. H1 antagonist - Wikipedia

    en.wikipedia.org/wiki/H1_antagonist

    H 1 antagonists, also called H 1 blockers, are a class of medications that block the action of histamine at the H 1 receptor, helping to relieve allergic reactions.Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.

  3. Histidine decarboxylase - Wikipedia

    en.wikipedia.org/wiki/Histidine_decarboxylase

    In mammals, histamine is an important biogenic amine with regulatory roles in neurotransmission, gastric acid secretion and immune response. [1] [2] Histidine decarboxylase is the sole member of the histamine synthesis pathway, producing histamine in a one-step reaction. Histamine cannot be generated by any other known enzyme.

  4. Antihistamine - Wikipedia

    en.wikipedia.org/wiki/Antihistamine

    [4] [5] Normally, histamine binds to the H 1 receptor and heightens the receptor's activity; the receptor antagonists work by binding to the receptor and blocking the activation of the receptor by histamine; by comparison, the inverse agonists bind to the receptor and both block the binding of histamine, and reduce its constitutive activity, an ...

  5. 16 Ways to Get Rid of Hives, According to Doctors - AOL

    www.aol.com/16-ways-rid-hives-according...

    Here's what happens behind the scenes: Your body stores the chemical histamine inside its cells, according to the American Academy of Dermatology (AAD). When you encounter a threat, your immune ...

  6. Mast cell stabilizer - Wikipedia

    en.wikipedia.org/wiki/Mast_cell_stabilizer

    They block mast cell degranulation, stabilizing the cell and thereby preventing the release of histamine and related mediators. One suspected pharmacodynamic mechanism is the blocking of IgE-regulated calcium channels. Without intracellular calcium, the histamine vesicles cannot fuse to the cell membrane and degranulate. [1]

  7. H3 receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/H3_receptor_antagonist

    An H 3 receptor antagonist is a type of antihistaminic drug used to block the action of histamine at H 3 receptors.. Unlike the H 1 and H 2 receptors which have primarily peripheral actions, but cause sedation if they are blocked in the brain, H 3 receptors are primarily found in the brain and are inhibitory autoreceptors located on histaminergic nerve terminals, which modulate the release of ...

  8. Histamine liberators - Wikipedia

    en.wikipedia.org/wiki/Histamine_liberators

    Histamine is an organic compound that primarily functions in service of the human body's immune responses as well as for the regulation of many physiological functions. [1] Since their discovery in 1910, [ 2 ] histamines have been known to trigger inflammatory responses such as itching as part of an immune response to foreign pathogens; for ...

  9. Diphenhydramine - Wikipedia

    en.wikipedia.org/wiki/Diphenhydramine

    Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.