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  2. Melanocortin 2 receptor accessory protein - Wikipedia

    en.wikipedia.org/wiki/Melanocortin_2_receptor...

    The mutations in the MRAP gene caused the congenital disorder familial glucocorticoid deficiency type 2 (FGD-2). FGD-2 is an autosomal recessive disease with early childhood onset of recurrent infections, hypoglycaemia, skin hyperpigmentation, and failure to thrive due to low glucocorticoids levels. If left untreated, it could be fatal.

  3. Glucocorticoid deficiency - Wikipedia

    en.wikipedia.org/wiki/Glucocorticoid_deficiency

    Glucocorticoid deficiency can be caused by inherited genetic disorders that affect the production of cortisol in the adrenal glands, such as familial glucocorticoid deficiency (FGD). [3] FGD is a group of monogenic recessive disorders caused by disease-causing variants in genes involved in cortisol biosynthesis. [ 4 ]

  4. Glucocorticoid deficiency 1 - Wikipedia

    en.wikipedia.org/wiki/Glucocorticoid_deficiency_1

    Glucocorticoid deficiency 1 is an adrenocortical failure characterized by low levels of plasma cortisol produced by the adrenal gland despite high levels of plasma ACTH. This is an inherited disorder with several different causes which define the type.

  5. Hill equation (biochemistry) - Wikipedia

    en.wikipedia.org/wiki/Hill_equation_(biochemistry)

    The Hill coefficient is a measure of ultrasensitivity (i.e. how steep is the response curve). The Hill coefficient, n {\displaystyle n} or n H {\displaystyle n_{H}} , may describe cooperativity (or possibly other biochemical properties, depending on the context in which the Hill equation is being used).

  6. Congenital adrenal hyperplasia due to 21-hydroxylase deficiency

    en.wikipedia.org/wiki/Congenital_adrenal...

    The glucocorticoids provide a reliable substitute for cortisol, thereby reducing ACTH levels. Reducing ACTH also reduces the stimulus for continued hyperplasia and overproduction of androgens. In other words, glucocorticoid replacement is the primary method of reducing the excessive adrenal androgen production in both sexes.

  7. ACTH receptor - Wikipedia

    en.wikipedia.org/wiki/ACTH_receptor

    Mutations in this receptor cause familial glucocorticoid deficiency (FGD) type 1, in which patients have high levels of serum ACTH and low levels of cortisol. [19] [20] Mutation of the receptor gene causes 25% of FGD, and mutation on the MRAP gene causes 20% of FGD. Mutations of ACTH can also contribute to this pathology: mutation of the ...

  8. Glucocorticoid remediable aldosteronism - Wikipedia

    en.wikipedia.org/wiki/Glucocorticoid_remediable...

    Glucocorticoid remediable aldosteronism also describable as aldosterone synthase hyperactivity, is an autosomal dominant disorder in which the increase in aldosterone secretion produced by ACTH is no longer transient.

  9. IC50 - Wikipedia

    en.wikipedia.org/wiki/IC50

    The IC 50 of a drug can be determined by constructing a dose-response curve and examining the effect of different concentrations of antagonist on reversing agonist activity. IC 50 values can be calculated for a given antagonist by determining the concentration needed to inhibit half of the maximum biological response of the agonist. [ 4 ]