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[3] HMB-PP is the physiological activator ("phosphoantigen") for human Vγ9/Vδ2 T cells, the major γδ T cell population in peripheral blood. With a bioactivity of 0.1 nM it is 10,000-10,000,000 times more potent than any other natural compound, such as IPP or alkyl amines. HMB-PP functions in this capacity by binding the B30.2 domain of ...
4-Hydroxy-3-methoxymethamphetamine (HMMA) is an active metabolite of 3,4-methylenedioxymethamphetamine (MDMA). [ 1 ] [ 2 ] [ 3 ] It is a slightly more potent stimulant than MDMA in rodents. [ 4 ] The drug is substantially less potent than MDMA as a monoamine releasing agent in vitro .
Recently, analogs of GHB, such as 4-hydroxy-4-methylpentanoic acid (UMB68) have been synthesised and tested on animals, in order to gain a better understanding of GHB's mode of action. [114] Analogues of GHB such as 3-methyl-GHB, 4-methyl-GHB , and 4-phenyl-GHB have been shown to produce similar effects to GHB in some animal studies, but these ...
The 4-hydroxy analogue of αMT has been looked at in human subjects. It is reported to be markedly visual in its effects, with some subjects reporting dizziness and a depressed feeling. There were, however, several toxic signs at doses of 15 to 20 milligrams orally, including abdominal pain, tachycardia , increased blood pressure and, with ...
4-Hydroxy-3-methoxyamphetamine (HMA), also known as 3-O-methyl-α-methyldopamine, is an active metabolite of 3,4-methylenedioxymethamphetamine (MDMA). [ 1 ] [ 2 ] [ 3 ] It is substantially less potent than MDMA or 3,4-methylenedioxyamphetamine (MDA) as a monoamine releasing agent in vitro .
The vapor is heavier than air, so it can accumulate at low points. It is explosive at concentrations between 1.4 and 11.4%. [16] Concentrations in the air high enough to be flammable are intolerable to humans due to the irritating nature of the vapor. [12] Butanone fires should be extinguished with carbon dioxide, dry agents, or alcohol ...
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase is an iron-sulfur protein that contains either a [3Fe-4S] or a [4Fe-4S] cluster. References This ...
Methylone is the substituted cathinone analogue of 3,4-methylenedioxymethamphetamine (MDMA) and the 3,4-methylenedioxy analog of methcathinone. The only structural difference of methylone with respect to MDMA is the substitution of 2 hydrogen atoms by 1 oxygen atom in the β position of the phenethylamine core, forming a ketone group .