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Methylchloroisothiazolinone, also referred to as MCI, is the organic compound with the formula S(C 2 HCl)C(O)N(CH 3).It is a white solid that melts near room temperature. The compound is an isothiazolinone, a class of heterocycles used as biocides.
Chloromethylisothiazolinone (CMIT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MIT) are popular derivatives. A 3:1 mixture of CMIT:MIT is sold as Kathon. Kathon is supplied as a concentrated stock solution containing from 1.5 to 15% of CMIT/MIT. For applications the recommended use level is from 6 ppm to 75 ppm active ...
In the United States, the Environmental Protection Agency has a 1998 data sheet on methylisothiazolinone in their Pesticides section [13] which reads in part "Human Health Assessment: Toxicity: In studies using laboratory animals, methylisothiazolinone has been shown to be of moderate acute toxicity by the oral and inhalation routes. It is ...
[20] 3-Methylcrotonyl-CoA carboxylase deficiency is characterized by increased 3-hydroxyisovaleric acid and 3-methylcrotonylglycine levels in the urine. The acylcarnitines profile shows elevated concentrations of 3-hydroxyisovalerylcarnitine as well as an increased ratio of 3-hydroxyisovalerylcarnitine to propionylcarnitine.
For most substances presented, the optimal levels are the ones normally found in the population as well. More specifically, optimal levels are generally close to a central tendency of the values found in the population. However, usual and optimal levels may differ substantially, most notably among vitamins and blood lipids, so these tables give ...
Signs and symptoms of methemoglobinemia (methemoglobin level above 10%) include shortness of breath, cyanosis, mental status changes (~50%), headache, fatigue, exercise intolerance, dizziness, and loss of consciousness. [5] People with severe methemoglobinemia (methemoglobin level above 50%) may exhibit seizures, coma, and death (level above 70 ...
Methylenetetrahydrofolate reductase deficiency is the most common genetic cause of elevated serum levels of homocysteine (hyperhomocysteinemia). It is caused by genetic defects in MTHFR, which is an important enzyme in the methyl cycle. [1] Common variants of MTHFR deficiency are asymptomatic and have only minor effects on disease risk. [2]
[6] [7] [8] The purpose of measuring MICs and grading microbes is to enable physicians to prescribe the most appropriate antimicrobial treatment. The first step in drug discovery is often measurement of the MICs of biological extracts , isolated compounds or large chemical libraries against bacteria and fungi of interest.