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Image labeled in German, but "Mantel-zone" visible near center. The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center. [1] It is also known as the "corona". [2] It contains transient lymphocytes. [3] It is the location of the lymphoma in mantle cell ...
A lymph node, or lymph gland, [1] is ... Histology of a normal lymphoid follicle, showing dark, light, mantle and marginal zones. A lymph node is divided into ...
Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer's patches, and the spleen [1] – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation aimed at achieving higher affinity) during a normal immune response ...
Mantle cell lymphoma (MCL) is a type of non-Hodgkin's lymphoma, comprising about 6% of cases. [1] [2] It is named for the mantle zone of the lymph nodes where it develops.[3] [4] The term 'mantle cell lymphoma' was first adopted by Raffeld and Jaffe in 1991.
Follicular hyperplasia can be distinguished among other diseases by observing the density of a lymph follicle on low magnification. Lymph nodes with reactive follicles contain extensions outside its capsule, follicles present throughout the entire node, obvious centroblasts and the absence or diminishing mantle zones.
ISFN and ISMCL are pathological accumulations of lymphocytes in the germinal centers and mantle zones, respectively, of the follicles that populate lymphoid organs such as lymph nodes. These lymphocytes are monoclonal (i.e. descendants of a single ancestral cell) B-cells that may develop into follicular (FL) and mantle cell (MCL) lymphomas ...
In humans, but not rodents, marginal zone B cells are also located in the inner wall of the subcapsular sinus of lymph nodes, the epithelium of tonsillar crypts, and the sub-epithelial area of mucosa-associated lymphoid tissues including the sub-epithelial dome of intestinal Peyer's patches. [2]
These malignancies appear to have been primarily marginal zone B-cell lymphomas of the splenic marginal zone B-cell, splenic lymphoma/leukemia unclassifiable, hairy cell leukemia, and possibly Waldenström's macroglobulinemia. MBL-MZ requires further studies to evaluate its frequencies, rate of progression to malignancy, and treatment.
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