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p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates , where they prevent cancer formation. [ 5 ]
The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. [5] [6] In humans, the Bcl-2-binding component 3 protein is encoded by the BBC3 gene. [5] [6] The expression of PUMA is regulated by the tumor suppressor p53.
Mdm2 has been identified as a p53 interacting protein that represses p53 transcriptional activity. Mdm2 achieves this repression by binding to and blocking the N-terminal trans-activation domain of p53. Mdm2 is a p53 responsive gene—that is, its transcription can be activated by p53.
In the field of genetics, a suicide gene is a gene that will cause a cell to kill itself through the process of apoptosis (programmed cell death). Activation of a suicide gene can cause death through a variety of pathways, but one important cellular "switch" to induce apoptosis is the p53 protein.
2024 Senegalese presidential election. President of Senegal Macky Sall states that he will leave the presidency in April, but does not give a specific date for the presidential election, which was postponed earlier this month. Science and technology. Moons of Uranus, Moons of Neptune
Hoda Kotb is feeling the love on her final day on the Today show. The 60-year-old co-anchor exited the NBC morning show on Friday, Jan. 10, and was cheered on by fans from across the country, who ...
With the 4-part documentary series SNL50: Beyond Saturday Night, fans will get new details of what it was like to work there, along with the chance to hear from cast members past and present about ...
This is a list of episodes for The Daily Show, a late-night talk and satirical news television program airing on Comedy Central, during 2024. [1]Following the departure of host Trevor Noah at the end of 2022, a series of guest hosts from both within and outside The Daily Show ' s correspondents roster filled the program's anchor chair throughout 2023, each sitting in for a one-week assignment. [2]