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BCG therapy is done by intravesical instillation (drug administration into the urinary bladder via a catheter) and has been used since 1970 on cancer patients. [ 5 ] Due to the necrotic and hypoxic regions of tumor cells (area of treatment resistance), drug delivery of chemotherapy can be impaired.
The first report of minicells in the scientific literature dates to 1930., [3] but the first use of the name "minicell" dates to 1967 [2] Minicells of a variety of gram negative [4] and gram positive [5] [6] bacteria, including Escherichia coli [7] and Salmonella enterica, [8] have been reported, but in principle, minicells could be generated for any bacterial species that can be genetically ...
Design of engineered live bacterial therapeutics [1]. Bacterial therapy is the therapeutic use of bacteria to treat diseases.Bacterial therapeutics are living medicines, and may be wild type bacteria (often in the form of probiotics) or bacteria that have been genetically engineered to possess therapeutic properties that is injected into a patient.
The initial discovery of this family of proteins is attributed to Adler et al. (1967). First identified as E. coli mutants that could not produce a properly localized septum, resulting in the generation of minicells [1] [2] due to mislocalized cell division occurring near the bacterial poles. This caused miniature vesicles to pinch off, void of ...
For breast cancer, he emphasized the importance of early intervention and advanced treatment modalities. "Aggressive treatments, including lumpectomy, hormone therapy and immunotherapy, have saved ...
Bacteria involved in causing and treating cancers. Cancer bacteria are bacteria infectious organisms that are known or suspected to cause cancer. [1] While cancer-associated bacteria have long been considered to be opportunistic (i.e., infecting healthy tissues after cancer has already established itself), there is some evidence that bacteria may be directly carcinogenic.
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