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Concizumab, sold under the brand name Alhemo, is a monoclonal antibody used for the treatment of hemophilia A and hemophilia B. [5] [8] It is an anti-tissue factor pathway inhibitor. [5] [8] The most common adverse reactions include injection site reactions and hives (urticaria). [11]
Acquired haemophilia A (AHA) is a rare but potentially life-threatening bleeding disorder characterized by autoantibodies directed against coagulation factor VIII.These autoantibodies constitute the most common spontaneous inhibitor to any coagulation factor and may induce spontaneous bleeding in patients with no previous history of a bleeding disorder.
However, some hemorrhoids will not respond to topical anti-inflammatory suppositories and creams and may need additional therapy including the application of thermal therapies, a rubber-band ...
Factor VIII was first identified in the 1940s and became available as a medication in the 1960s. [15] [16] Recombinant factor VIII was first made in 1984 and approved for medical use in the United States in 1992. [17] [18] It is on the World Health Organization's List of Essential Medicines. [19]
However, the long-term benefit is greater in those with grade III hemorrhoids as compared to rubber band ligation. [45] It is the recommended treatment in those with a thrombosed external hemorrhoid if carried out within 24–72 hours. [6] [16] Evidence to support this is weak, however. [28]
For quick relief from painful and itchy external hemorrhoids, head to your pharmacy for an over-the-counter hemorrhoid cream or suppository that contains witch hazel (like Tucks pads) or ...
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