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Dosage is 11 mg/kg not to exceed 1 g as a single dose. [citation needed] Albendazole, a broad-spectrum antihelminthic agent that decreases ATP production in the worm, causing energy depletion, immobilization, and finally death. Dosage is 400 mg given as single oral dose (contraindicated during pregnancy and children under 2 years).
Albendazole is a broad-spectrum antihelmintic and antiprotozoal agent of the benzimidazole type. [3] It is used for the treatment of a variety of intestinal parasite infections, including ascariasis, pinworm infection, hookworm infection, trichuriasis, strongyloidiasis, taeniasis, clonorchiasis, opisthorchiasis, cutaneous larva migrans, giardiasis, and gnathostomiasis, among other diseases.
Those recommended by the World Health Organization for ascariasis are: albendazole, mebendazole, levamisole and pyrantel pamoate. [2] Single-dose of albendazole, mebendazole, and ivermectin are effective against ascariasis. They are effective at removing parasites and eggs from the intestines. [34]
Mebendazole is given twice a day for three consecutive days, while albendazole is given as a single dose. WHO recommends annual treatment in areas where between 20 and 50% of people are infected, and a twice a year treatment if it is over 50%; and in low risk situations (i.e. less than 20% prevalence) case-by-case treatment.
Despite lack of larvicidal effects, albendazole (20–40 mg/kg/d for 1–4 weeks) has been used to treat many cases. [4] Baylisascaris species.
This includes ascariasis, hookworm infections, enterobiasis (pinworm infection), trichostrongyliasis, and trichinellosis. [2] It is taken by mouth. [2] Side effects include nausea, headache, dizziness, trouble sleeping, and rash. [2] A lower dose should be used in people with liver disease. [2]
Nitazoxanide – readily kills Ascaris lumbricoides, [9] and also possesses antiprotozoal effects. [10] This is also an ascaricide. Oxamniquine – effective against flatworms (e.g., tapeworms and schistosoma) Praziquantel – effective against flatworms (e.g., tapeworms and schistosoma)
The typical adult therapy for oesophagostomiasis is a single 400 mg dose of albendazole (200 mg for children) or pyrantel pamoate. [7] Albendazole works by binding to the free beta tubulin, which inhibits tubulin polymerization. This results in the inhibition of glucose uptake by the Oesophagostomum.
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