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Structural model at atomic resolution of bacteriophage T4 [1] The structure of a typical myovirus bacteriophage Anatomy and infection cycle of bacteriophage T4.. A bacteriophage (/ b æ k ˈ t ɪər i oʊ f eɪ dʒ /), also known informally as a phage (/ ˈ f eɪ dʒ /), is a virus that infects and replicates within bacteria and archaea.
d'Hérelle was a self-taught microbiologist. In 1917 he discovered that "an invisible antagonist", when added to bacteria on agar, would produce areas of dead bacteria. The antagonist, now known to be a bacteriophage, could pass through a Chamberland filter. He accurately diluted a suspension of these viruses and discovered that the highest ...
In the same year, 1898, Friedrich Loeffler (1852–1915) and Paul Frosch (1860–1928) passed the first animal virus through a similar filter and discovered the cause of foot-and-mouth disease. [5] The first human virus to be identified was the yellow fever virus. [6]
Bacteriophage Lambda Structure at Atomic Resolution [1] Enterobacteria phage λ (lambda phage, coliphage λ, officially Escherichia virus Lambda) is a bacterial virus, or bacteriophage, that infects the bacterial species Escherichia coli (E. coli). It was discovered by Esther Lederberg in 1950. [2]
Frederick William Twort FRS [1] (22 October 1877 – 20 March 1950) was an English bacteriologist and was the original discoverer in 1915 of bacteriophages (viruses that infect bacteria). [4]
In 1946, Luria made a finding that was destined to open up a new insight on how the stability of DNA is achieved (see Luria, [5] pg. 96). What he discovered was that when, after UV irradiation, two or more "dead" phage entered the same bacterial cell, they often became alive again and produced normal live progeny. [9]
Although bacteriophages cannot infect human cells, they are found in abundance in the human virome. [7] Phageome research in humans has largely focused on the gut, however it is also being investigated in other areas like the skin, [ 8 ] blood, [ 9 ] and mouth. [ 10 ]
These two researchers isolated T3, T4, T5, and T6 from E.coli. Also, in 1932, the researcher J. Bronfenbrenner had studied and worked on the T2 phage, at which the T2 phage was isolated from the virus. [39] This isolation was made from a fecal material rather than from sewerage.