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Some studies attribute filaggrin an important role in keeping the skin surface slightly acidic, through a breaking down mechanism to form histidine and subsequently trans-urocanic acid, [6] however others have shown that the filaggrin–histidine–urocanic acid cascade is not essential for skin acidification. [7]
Histidine (symbol His or H) [2] is an essential amino acid that is used in the biosynthesis of proteins.It contains an α-amino group (which is in the protonated –NH 3 + form under biological conditions), a carboxylic acid group (which is in the deprotonated –COO − form under biological conditions), and an imidazole side chain (which is partially protonated), classifying it as a ...
Tritoqualine, also known as hypostamine, is an inhibitor of the enzyme histidine decarboxylase and therefore an atypical antihistamine, used for the treatment of urticaria and allergic rhinitis [1] with no known adverse effects. [citation needed]
n/a Ensembl ENSG00000143631 n/a UniProt P20930 n/a RefSeq (mRNA) NM_002016 n/a RefSeq (protein) NP_002007 n/a Location (UCSC) Chr 1: 152.3 – 152.33 Mb n/a PubMed search n/a Wikidata View/Edit Human Filaggrin (fil ament aggr egating prote in) is a filament-associated protein that binds to keratin fibers in epithelial cells. Ten to twelve filaggrin units are post-translationally hydrolyzed ...
Manhattan-based dermatologist Dr. Brendan Camp, M.D., said that toasted skin syndrome, officially known as erythema ab igne (EAI), is a "pattern of discoloration that occurs in areas of skin after ...
Histidinol dehydrogenase catalyzes the terminal step in the biosynthesis of histidine in bacteria, fungi, and plants, the four-electron oxidation of L-histidinol to histidine. In 4-electron dehydrogenases, a single active site catalyses 2 separate oxidation steps: oxidation of the substrate alcohol to an intermediate aldehyde ; and oxidation of ...
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