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[1] [2] [3] The medication is given once a month by injection into muscle. [1] [2] [3] EV/NETE is approved for use in at least 36 countries, and is the most widely used combined injectable contraceptive. [5] [3] It is available widely throughout Latin America, in a few Asian and African countries, and in Turkey. [6] [7] [8]
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EC/MPA is available in the form of a microcrystalline aqueous suspension of 5 mg EC and 25 mg MPA given in a 0.5 mL aqueous solution for intramuscular injection once per month. [10] It is provided in the form of single-dose vials and ampoules. [10] The particle sizes of the formulation are 93% within a range of 5 to 16 μm. [11]
Estradiol, testosterone, and prolactin levels with 100 mg/month estradiol undecylate in oil by intramuscular injection in 14 to 28 men with prostate cancer. [65] A follow-up of the study with more men and with additional hormones was also subsequently published. [70] Sources were Jacobi & Altwein (1979) and Derra (1981). [65] [70]
A single intramuscular injection of estradiol valerate/norethisterone enanthate (5 mg/50 mg) (Mesigyna) has been found to strongly suppress testosterone levels in men. [33] Testosterone levels decreased from a baseline of ~503 ng/dL to a trough of ~30 ng/dL (a 94% decrease) which occurred at day 7 post-injection. [33]
Semaglutide, the active ingredient in Ozempic and Wegovy, is a glucagon-like peptide-1 (GLP-1) receptor agonist taken as a once-weekly injection. 5 Simple Steps to Injecting Semaglutide for Weight ...
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