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DISH has no indication of a genetic link, is primarily thoracic and does not affect organs other than the lungs, and only indirectly due to the fusion of the rib cage. [ 10 ] Long-term treatment of acne with vitamin derived retinoids , such as etretinate [ 11 ] and acitretin, [ 12 ] have been associated with extraspinal hyperostosis.
Spondylocostal dysostosis, also known as Jarcho-Levin syndrome (JLS), is a rare, heritable axial skeleton growth disorder. It is characterized by widespread and sometimes severe malformations of the vertebral column and ribs, shortened thorax, and moderate to severe scoliosis and kyphosis.
Spondylosis is the degeneration of the vertebral column from any cause. In the more narrow sense, it refers to spinal osteoarthritis , the age-related degeneration of the spinal column, which is the most common cause of spondylosis.
Spondylosis deformans is a disease of the spine in humans and other vertebrates. It occurs when intervertebral discs begin to degenerate, ...
Thoracic spinal stenosis, at the level of the mid-back, is much less common. [13] In lumbar stenosis, the spinal nerve roots in the lower back are compressed which can lead to symptoms of sciatica (tingling, weakness, or numbness that radiates from the low back and into the buttocks and legs). [citation needed]
Microscopically visible ileal inflammation is seen in about 50% of people with spondyloarthritis and ankylosing spondylitis during ileocolonoscopy. [11] [4] There seems to be an immunological connection between the gut inflammation observed in Crohn's disease and ankylosing spondylitis. [12]
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Axial spondyloarthritis can be differentiated from peripheral spondyloarthritis in terms of the areas of the body affected. The axial form of the disease primarily affects the spine, pelvis and thoracic cage, whereas the peripheral form mainly targets the arms and legs. [10] Axial spondyloarthritis can be divided into two classes:
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