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Ponazuril (), sold by Merial, Inc., [1] now part of Boehringer Ingelheim, [2] under the trade name Marquis (15% w/w ponazuril), is a drug currently approved for the treatment of equine protozoal myeloencephalitis (EPM) in horses, caused by coccidia Sarcocystis neurona.
Horses contract EPM from contaminated feed or water. Horses cannot pass the disease among themselves; that is, one horse cannot contract the disease from another infected horse. The horse is a dead-end, or aberrant, host of the parasite. Although all horses are believed to be susceptible to EPM the disease is usually found in younger horses ...
Neospora hughesi is an obligate protozoan apicomplexan parasite that causes myelitis and equine protozoal myeloencephalitis (EPM) in horses, and has only been documented in North America. [1] EPM is a neurological disease from lesions in the spinal cord , brain stem , or brain from parasites such as N. hughesi or Sarcocystis neurona . [ 2 ]
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The protozoan, S. neurona, is a member of the genus Sarcocystis, and is most commonly associated with equine protozoal myeloencephalitis (EPM). [2] S. neurona can be easily cultivated and genetically manipulated, hence its common use as a model to study numerous aspects of cell biology .
The horse is evaluated in motion, usually at the walk and trot, but occasionally also in the canter. The walk is often the best gait to evaluate foot placement. [10] The trot is generally the best gait to localize the lameness to a particular leg, because it is a symmetrical gait where the front half of the horse and the back half move in ...
EIPH often occurs in horses that race at high speeds, with the number of affected race horses increasing in proportion to the speed and intensity of the exercise. It may occur in racing Thoroughbreds (flat racing, steeplechasing or jump racing), American Quarter Horses (incidence of 50–75%), Standardbreds (incidence of 40–60%), Arabians, and Appaloosas.