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In molecular biology, 2'-5'-oligoadenylate synthetase (2-5A synthetase) is an enzyme (EC 2.7.7.84) that reacts to interferon signal. It is an antiviral enzyme that counteracts viral attack by degrading RNAs , both viral and host.
2'-5'-oligoadenylate synthetase 1 is an enzyme that in humans is encoded by the OAS1 gene. [ 5 ] [ 6 ] This gene encodes a member of the 2-5A synthetase family, which include essential proteins involved in the innate immune response to viral infection.
2'-5'-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene. [ 5 ] [ 6 ] This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection.
24014 Ensembl ENSG00000135828 ENSMUSG00000066800 UniProt Q05823 Q05921 RefSeq (mRNA) NM_021133 NM_011882 RefSeq (protein) NP_066956 NP_036012 Location (UCSC) Chr 1: 182.57 – 182.59 Mb Chr 1: 153.63 – 153.64 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ribonuclease L or RNase L (for latent), known sometimes as ribonuclease 4 or 2'-5' oligoadenylate synthetase-dependent ...
It also can work to mask the drug peptide from peptide-degrading enzymes in the brain [7] Also a "targetor" molecule could be attached to the drug that helps it pass through the barrier and then once inside the brain, is degraded in such a way that the drug cannot pass back through the brain. Once the drug cannot pass back through the barrier ...
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The n-back task is a continuous performance task that is commonly used as an assessment in psychology and cognitive neuroscience to measure a part of working memory and working memory capacity. [1] The n-back was introduced by Wayne Kirchner in 1958. [2]
Oligodendrocytes are a type of glial cell, non-neuronal cells in the central nervous system.They arise during development from oligodendrocyte precursor cells (OPCs), [8] which can be identified by their expression of a number of antigens, including the ganglioside GD3, [9] [10] [11] the NG2 chondroitin sulfate proteoglycan, and the platelet-derived growth factor-alpha receptor subunit (PDGF ...