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Diphenhydramine, sold under the brand name Benadryl among others, is an antihistamine and sedative.It is a first-generation H 1-antihistamine and it works by blocking certain effects of histamine, which produces its antihistamine and sedative effects.
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Benadryl Allergy is widely used as a sleep aid among adults. While it is not marketed as an over-the-counter (OTC) sleeping aid, most versions of Benadryl contain diphenhydramine, a drug with sedative properties. [6] Diphenhydramine (Benadryl) has also been used by parents to help improve their infant's sleep habits.
Prednisone is a synthetic glucocorticoid used for its anti-inflammatory and immunosuppressive properties. [36] [37] Prednisone is a prodrug; it is metabolised in the liver by 11-β-HSD to prednisolone, the active drug. Prednisone has no substantial biological effects until converted via hepatic metabolism to prednisolone. [38]
Intermittent use of topical steroids for atopic dermatitis is safe and does not cause skin thinning. [6] [7] [8] Skin atrophy can occur with both prescription and over the counter steroids creams. [9] Low doses of prednisone by mouth can also result in skin atrophy.
"Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors".
Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and autoimmune conditions [17] such as asthma, [18] uveitis, pyoderma gangrenosum, rheumatoid arthritis, urticaria, [19] angioedema, [19] ulcerative colitis, pericarditis ...
Interactions with other drugs, food and drink, and other factors may increase or decrease the effect of certain analgesics and alter their half-life. Because some listed analgesics are prodrugs or have active metabolites , individual variation in liver enzymes (e.g., CYP2D6 enzyme) may result in significantly altered effects.
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