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The biogenesis of the peroxisomal membrane and the insertion of peroxisomal membrane proteins (PMPs) requires the peroxins PEX19, PEX3, and PEX16. PEX19 is a PMP receptor and chaperone, which binds the PMPs and routes them to the peroxisomal membrane, where it interacts with PEX3, a peroxisomal integral membrane protein.
Peroxins serve several functions including the recognition of cytoplasmic proteins that contain peroxisomal targeting signals (PTS) that tag them for transport by peroxisomal proteins to the peroxisome. Peroxins are structurally diverse and have been classified to different protein families.
20524 Ensembl ENSG00000100372 ENSMUSG00000022404 UniProt O43808 O70579 RefSeq (mRNA) NM_001282726 NM_001282727 NM_006358 NM_011399 RefSeq (protein) NP_001269655 NP_001269656 NP_006349 NP_035529 Location (UCSC) Chr 22: 40.77 – 40.82 Mb Chr 15: 81.2 – 81.25 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal membrane protein PMP34 is a protein that in humans is encoded by ...
18633 Ensembl ENSG00000121680 ENSMUSG00000027222 UniProt Q9Y5Y5 Q91XC9 RefSeq (mRNA) NM_004813 NM_057174 NM_145122 RefSeq (protein) NP_004804 NP_476515 NP_660104 Location (UCSC) Chr 11: 45.91 – 45.92 Mb Chr 2: 92.21 – 92.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal membrane protein PEX16 is a protein that in humans is encoded by the PEX16 gene. Function The ...
72129 Ensembl ENSG00000162928 ENSMUSG00000020283 UniProt Q92968 Q9D0K1 RefSeq (mRNA) NM_002618 NM_023651 RefSeq (protein) NP_002609 NP_076140 Location (UCSC) Chr 2: 61.02 – 61.05 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal membrane protein PEX13 is a protein that in humans is encoded by the PEX13 gene. It located on chromosome 2 next to KIAA1841 Interactions ...
Peroxisomal biogenesis factor 19 is a protein that in humans is encoded by the PEX19 gene. [5] [6] [7] Interactions.
56535 Ensembl ENSG00000034693 ENSMUSG00000019809 UniProt P56589 Q7Z6V3 Q9QXY9 RefSeq (mRNA) NM_003630 NM_001164195 NM_019961 NM_001347361 RefSeq (protein) NP_003621 NP_001157667 NP_001334290 NP_064345 Location (UCSC) Chr 6: 143.45 – 143.49 Mb Chr 10: 13.4 – 13.43 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Peroxisomal biogenesis factor 3 is a protein that in humans is encoded ...
A distinct motif is used for proteins destined for the peroxisomal membrane called the "mPTS" motif, which is more poorly defined and may consist of discontinuous subdomains. [2] One of these usually is a cluster of basic amino acids ( arginines and lysines) within a loop of protein (i.e., between membrane spans) that will face the matrix.
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