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Sumatriptan is effective for ending or relieving the intensity of migraine and cluster headaches. [9] It is most effective when taken early after the start of the pain. [9] Injected sumatriptan is more effective than other formulations. [10] Oral sumatriptan can be used also in the treatment of post-dural puncture headache. [11]
Triptans are a mid-line treatment suitable for many migraineurs with typical attacks. They may not work for atypical or unusually severe migraine attacks, transformed migraine, or status migrainosus (continuous migraine). Triptans are highly effective, reducing the symptoms or aborting the attack within 30 to 90 minutes in 70–80% of patients. [6]
Cipriani noted that, “despite their effectiveness, triptans are underused,” as, “according to European population-based data, only 3.4–22.4% of people with migraine are using triptans.”
A meta-analysis of 53 clinical trials has shown that all triptans are effective for treating migraine at marketed doses and that naratriptan, although less effective than sumatriptan and rizatriptan was more effective than placebo in reducing migraine symptoms at two hours [3] and efficacy was demonstrated in almost two thirds of subjects after four hours of treatment.
Triptans: After trying NSAIDs, triptans are the go-to drug for many people with migraines. “These are migraine-specific pain medications,” says VanderPluym. “These are migraine-specific pain ...
Almotriptan (trade name Axert and others) is a triptan medication discovered and developed by Almirall for the treatment of heavy migraine headache. It was patented in 1992 and approved for medical use in 2000. [4]
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