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  2. Short-chain acyl-coenzyme A dehydrogenase deficiency

    en.wikipedia.org/wiki/Short-chain_acyl-coenzyme...

    Mutations in the ACADS gene lead to inadequate levels of short-chain acyl-CoA dehydrogenase, which is important for breaking down short-chain fatty acids. Low levels of this enzyme halt short-chain fatty acids from being further broken down and processed in the mitochondria, consequently, these short-chain fatty acids are not converted into energy.

  3. Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency

    en.wikipedia.org/wiki/Long-chain_3-hydroxyacyl...

    Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency is a rare autosomal recessive fatty acid oxidation disorder [1] that prevents the body from converting certain fats into energy.

  4. Coenzyme A - Wikipedia

    en.wikipedia.org/wiki/Coenzyme_A

    Coenzyme A (CoA, SHCoA, CoASH) is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle. All genomes sequenced to date encode enzymes that use coenzyme A as a substrate , and around 4% of cellular enzymes use it (or a thioester ) as a substrate.

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  6. Very long-chain acyl-coenzyme A dehydrogenase deficiency

    en.wikipedia.org/wiki/Very_long-chain_acyl...

    VLCAD (very long-chain-acyl-dehydrogenase) deficiency is exclusively linked to genetic mutations in DNA. A change of the gene that codes for very long-chain-acyl-CoA-dehydrogenase (VLCAD) results in a deficiency or malfunction of the produced VLCAD enzyme. [7] This mutation occurs on chromosome 17 and can be altered via a variety of pathways. [4]

  7. Coenzyme A transferases - Wikipedia

    en.wikipedia.org/wiki/Coenzyme_A_transferases

    The acyl-CoA breaks at the thioester bond, forming a CoA and carboxylic acid. The carboxylic acid remains bound to the enzyme, but it is soon displaced by CoA and leaves. A new carboxylic acid (the CoA acceptor) enters and forms a new acyl-CoA. The new acyl-CoA is released, completing the transfer of CoA from one molecule to another.

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  9. Acetyl-CoA - Wikipedia

    en.wikipedia.org/wiki/Acetyl-CoA

    Acetyl-CoA (acetyl coenzyme A) is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism. [2]