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After Muller's classification of gene mutation, an isomorph was described as a silent point mutant with identical gene expression as the original allele. [4] [5] m/Df = m/Dp Therefore, with respect to the relationship between the original and mutated genes, one cannot talk about the effects of dominance and/or recessiveness. [4] [5] [6]
Hermann Joseph Muller (December 21, 1890 – April 5, 1967) was an American geneticist who was awarded the 1946 Nobel Prize in Physiology or Medicine, "for the discovery that mutations can be induced by X-rays". [2]
This can result in the populations having different genotypes, that can cause Dobzhansky–Muller incompatibilities. [9] Genes that are incompatible according to the Dobzhansky–Muller model require three criteria. 1. The gene reduces the fitness of the hybrid, 2. The gene has functionally diverged in each of the hybridising species and, 3.
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Illustration of chromosome crossover during genetic recombination. In evolutionary genetics, Muller's ratchet (named after Hermann Joseph Muller, by analogy with a ratchet effect) is a process which, in the absence of recombination (especially in an asexual population), results in an accumulation of irreversible deleterious mutations.