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Tinea cruris is treated by applying antifungal medications of the allylamine or azole type to the groin region. Studies suggest that allylamines (naftifine and terbinafine) are a quicker but more expensive form of treatment compared to azoles ( clotrimazole , econazole , ketoconazole , oxiconazole , miconazole , sulconazole ). [ 6 ]
Common side effects include paresthesia, rash, edema, and secondary infections. [1] In 2022, it was the 242nd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [3] [4]
Clotrimazole may be compounded with a glucocorticoid, such as betamethasone, in a topical cream for the treatment of tinea corporis (ringworm), tinea cruris (jock itch) and tinea pedis (athlete's foot). Although FDA-approved, clotrimazole–betamethasone combination cream is not the preferred treatment for dermatophyte infections due to ...
The side effects of oral treatment are significant and people without an infection should not take these drugs. [36] Azoles are the group of antifungals which act on the cell membrane of fungi. They inhibit the enzyme 14-alpha-sterol demethylase, a microsomal CYP, which is required for the biosynthesis of ergosterol for the cytoplasmic membrane.
Tinea corporis (also known as "ringworm", [2] tinea circinata, [11] and tinea glabrosa [2]) is a superficial fungal infection (dermatophytosis) of the arms and legs, especially on glabrous skin; however, it may occur on any part of the body, it present as annular, marginated plaque with thin scale and clear center.
They are usually used topically for the treatment of skin infections. [11] Naftifine Naftifine is used topically for the treatment of dermatophytosis, including tinea cruris (jock itch), tinea corporis (ringworm of the body), tinea pedis (athlete's foot) and tinea manuum (ringworm of the hand). It is available in creams or gels.
Naftifine hydrochloride (brand names include Exoderil and Naftin) is an allylamine antifungal drug for the topical treatment of tinea pedis, tinea cruris, and tinea corporis (topical fungal infections). Naftifine was invented at the Sandoz Research Institute in Vienna, Austria. It was the first successful antifungal medication of the allylamine ...
Butenafine is indicated for the topical treatment of tinea (pityriasis) versicolor due to Malassezia furfur, as well as athlete's foot (Tinea pedis), ringworm (Tinea corporis) and jock itch (Tinea cruris) due to Epidermophyton floccosum, Trichophyton mentagrophytes, Trichophyton rubrum, and Trichophyton tonsurans.