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Isolates that are multi-resistant to any other combination of anti-TB drugs but not to INH and RMP are not classed as MDR-TB. As of October 2006, "Extensively drug-resistant tuberculosis" (XDR-TB) is defined as MDR-TB that is resistant to quinolones and also to any one of kanamycin, capreomycin, or amikacin. [76]
Bedaquiline, sold under the brand name Sirturo, is a medication used for the treatment of active tuberculosis. [1] Specifically, it is used to treat multi-drug-resistant tuberculosis along with other medications for tuberculosis. [1] [8] [9] It is taken by mouth. [3] Common side effects include nausea, joint pains, headaches, and chest pain. [1]
Delamanid is sold under the brand name Deltyba, is a medication used to treat tuberculosis. [2] Specifically it is used, along with other antituberculosis medications, for active multidrug-resistant tuberculosis. [2] It is taken by mouth. [2] There are common side effects which include headache, dizziness, and nausea. [3]
Its potency is less than that of the current five first-line drugs (isoniazid, rifampicin, ethambutol, pyrazinamide, and streptomycin) for treating tuberculosis and its cost is higher, but it is still useful in the treatment of multidrug-resistant tuberculosis. [8] PAS is always used in combination with other anti-TB drugs. [citation needed]
It is used either alone or with other antituberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1] Pyridoxine may be used to decrease the risk of numbness. [2] It is not recommended in people with liver problems or severe kidney problems. [3] Use may not be suitable in children. [1]
It is used either along or with other anti-tuberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1]
It is used either by itself or along with other antituberculosis medication. [1] It is taken by mouth. [1] Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness. [2] Severe side effects include liver problems. [3]
Specifically it is a second line treatment used for active drug resistant tuberculosis. [1] It is given by injection into a vein or muscle. [1] Common side effects include kidney problems, hearing problems, poor balance, and pain at the site of injection. [1] Other side effects include paralysis resulting in the inability to breathe. [1]