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Condensed DNA often has surprising properties, which one would not predict from classical concepts of dilute solutions. Therefore, DNA condensation in vitro serves as a model system for many processes of physics, biochemistry and biology. [2] In addition, DNA condensation has many potential applications in medicine and biotechnology. [1]
In biology the term 'condensation' is used much more broadly and can also refer to liquid–liquid phase separation to form colloidal emulsions or liquid crystals within cells, and liquid–solid phase separation to form gels, [1] sols, or suspensions within cells as well as liquid-to-solid phase transitions such as DNA condensation during ...
File:DNA condensation.svg is a vector version of this file. It should be used in place of this PDF file. ... File:DNA polymerization.pdf → File:DNA condensation.svg ...
DNA can be twisted like a rope in a process called DNA supercoiling. With DNA in its "relaxed" state, a strand usually circles the axis of the double helix once every 10.4 base pairs, but if the DNA is twisted the strands become more tightly or more loosely wound. [43]
The nucleosome is the basic unit of DNA condensation and consists of a DNA double helix bound to an octamer of core histones (2 dimers of H2A and H2B, and an H3/H4 tetramer). About 147 base pairs of DNA coil around 1 octamer, and ~20 base pairs are sequestered by the addition of the linker histone (H1), and various length of "linker" DNA (~0 ...
Condensation reactions likely played major roles in the synthesis of the first biotic molecules including early peptides and nucleic acids. In fact, condensation reactions would be required at multiple steps in RNA oligomerization: the condensation of nucleobases and sugars , nucleoside phosphorylation , and nucleotide polymerization.
For example, in fission yeast, phosphorylation of the N-terminus of the SMC4 subunit regulates nuclear translocation of condensin during mitosis. [12] In budding yeast , condensin localizes to the nucleus throughout the cell cycle, and phosphorylation of the N-terminus of the SMC4 subunit is involved in the regulation of chromosome association ...
This relaxation can be reversed by deacetylation catalyzed by HDAC activity. Relaxed, transcriptionally active DNA is referred to as euchromatin. More condensed (tightly packed) DNA is referred to as heterochromatin. Condensation can be brought about by processes including deacetylation and methylation. [1]