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MIP-1γ is another macrophage inflammatory protein and according to the new nomenclature is named CCL9. [3] It is produced mainly by follicle-associated epithelial cells and is responsible for chemotaxis of dendritic cells and macrophages into Peyer's patches in gut through binding of CCR1. [11] MIP-1δ or MIP-5 (CCL15) binds also CCR1 and CCR3 ...
1230 12768 Ensembl ENSG00000163823 ENSMUSG00000025804 UniProt P32246 P51675 RefSeq (mRNA) NM_001295 NM_009912 RefSeq (protein) NP_001286 NP_034042 Location (UCSC) Chr 3: 46.2 – 46.21 Mb Chr 9: 123.76 – 123.77 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse C-C chemokine receptor type 1 is a protein that in humans is encoded by the CCR1 gene. CCR1 has also recently been designated ...
It is chemotactic for neutrophils, monocytes, and lymphocytes and elicits its effects by binding to cell surface chemokine receptors like CCR1 and CCR3. [ 2 ] [ 3 ] The human CCL15 gene spans four exons and is located in a head-to-tail orientation on chromosome 17 with the gene of another CC chemokine known as CCL14 .
C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. [5] In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3.
CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes [6] through binding to the receptors CCR1, CCR4 and CCR5. [5] Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta .
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