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The pathophysiology of obesity involves many possible pathophysiological mechanisms involved in its development and maintenance. [28] [29] This field of research had been almost unapproached until the leptin gene was discovered in 1994 by J. M. Friedman's laboratory. [30] These investigators postulated that leptin was a satiety factor.
Major trauma is a severe traumatic injury that has the potential to cause disability or death. Serious traumatic injury most often occurs as a result of traffic collisions. [11] Traumatic injury is the leading cause of death in people under the age of 45. [12] Blunt trauma injuries are caused by the forceful impact of an external object.
Necrosis (from Ancient Greek νέκρωσις (nékrōsis) 'death') is a form of cell injury which results in the premature death of cells in living tissue by autolysis. [1] The term "necrosis" came about in the mid-19th century and is commonly attributed to German pathologist Rudolf Virchow , who is often regarded as one of the founders of ...
Similar failure processes are involved in brain failure following reversal of cardiac arrest; [3] control of these processes is the subject of ongoing research. Repeated bouts of ischemia and reperfusion injury also are thought to be a factor leading to the formation and failure to heal of chronic wounds such as pressure sores and diabetic foot ...
The current of injury – also known as the demarcation current, hermann's demarcation current [1] or injury potential [2] – is the electric current from the central part of the body to an injured nerve or muscle, or to another injured excitable tissue. The injured tissue has a negative voltage compared to the central part of the body. [3]
Abdominal CT showing left renal artery injury. Blunt abdominal trauma (BAT) represents 75% of all blunt trauma and is the most common example of this injury. [3] Seventy-five percent of BAT occurs in motor vehicle crashes, [4] in which rapid deceleration may propel the driver into the steering wheel, dashboard, or seatbelt, [5] causing contusions in less serious cases, or rupture of internal ...
Hemostasis is maintained in the body via three mechanisms: Vascular spasm: Vasoconstriction is produced by vascular smooth muscle cells, and is the blood vessel's first response to injury. The smooth muscle cells are controlled by vascular endothelium, which releases intravascular signals to control the contracting properties.
In 2002, unintentional and intentional injuries were the fifth and seventh leading causes of deaths worldwide, accounting for 6.23% and 2.84% of all deaths. For research purposes the definition often is based on an Injury Severity Score (ISS) of greater than 15. [2]