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In 1911, the anaesthetist Arthur Ernest Guedel first described the use of self-administration of a nitrous oxide and oxygen mix. It was not until 1961 that the first paper was published by Michael Tunstall and others, describing the administration of a pre-mixed 50:50 nitrous oxide and oxygen mix, which led to the commercialisation of the product.
Nitrous oxide (N 2 O), commonly referred to as laughing gas, along with various street names, is an inert gas which can induce euphoria, dissociation, hallucinogenic states of mind, and relaxation when inhaled. [1] Nitrous oxide has no acute biochemical or cellular toxicity and is not metabolized in humans or other mammals.
It is for this reason that Entonox, a 50:50 gaseous mixture of nitrous oxide and oxygen, is suitable for use by para-medical staff such as ambulance officers: it provides sufficient nitrous oxide for pain relief with sufficient oxygen to avoid hypoxia. [7] [8]
The use of nitrous oxide as a recreational drug at "laughing gas parties", primarily arranged for the British upper class, became an immediate success beginning in 1799. While the effects of the gas generally make the user appear stuporous, dreamy and sedated, some people also "get the giggles" in a state of euphoria, and frequently erupt in ...
Nitrous cut-off or oxygen failure protection device, OFPD: the flow of medical nitrous-oxide is dependent on oxygen pressure. This is done at the regulator level. In essence, the nitrous-oxide regulator is a 'slave' of the oxygen regulator. i.e., if oxygen pressure is lost then the other gases can not flow past their regulator.
The first, conducted in 1844, consisted of having his assistant John Riggs dose him with nitrous oxide and then extract one of his teeth. [6] His later self-experimentation of ether and chloroform took place in 1848, and he eventually became addicted to chloroform due to excessive use. [ 7 ]
Cryo-S Painless cryoanalgesia device is the next generation of apparatus used by many experts in the field since 1992. The working medium for Cryo-S Painless is carbon dioxide: CO 2 (−78 °C) or nitrous oxide: N 2 O (−89 °C), very efficient and easy to use gases. Cryo-S Painless is controlled by a microprocessor and all the parameters are ...
Nitrous oxide is thought to be particularly non-toxic, though heavy long-term use can lead to a variety of serious health problems linked to the destruction of vitamin B12 and folic acid. [17] [18] Nitrous oxide "whippets" are small aerosol containers designed for charging whipped cream dispensers.
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