Search results
Results from the WOW.Com Content Network
In humans, the MSTN gene is located on the long (q) arm of chromosome 2 at position 32.2. [5] Myostatin (also known as growth differentiation factor 8, abbreviated GDF8) is a protein that in humans is encoded by the MSTN gene. [6] Myostatin is a myokine that is produced and released by myocytes and acts on muscle cells to inhibit muscle growth. [7]
Myostatin-related muscle hypertrophy is a rare genetic condition characterized by reduced body fat and increased skeletal muscle size. [1] Affected individuals have up to twice the usual amount of muscle mass in their bodies, but increases in muscle strength are not usually congruent. [ 2 ]
Double-muscled cattle are breeds of cattle that carry one of seven known mutations that limits and reduces the activity of the myostatin protein. Normally, myostatin limits the number of muscle fibers present at birth, and interfering with activity of this protein causes animals to be born with higher numbers of muscle fibers, consequently augmenting muscle growth.
The active-myostatin gene acts as a "governor" on muscle growth; myostatin is a protein that instructs muscles to stop growing. In effect, when inactive, as it is with Piedmontese cattle, it no longer prevents muscle development which is what allows for the hypertrophic condition sometimes referred to as "double muscling".
The Belgian Blue has a natural mutation in the myostatin gene which codes for the protein, myostatin ("myo" meaning muscle and "statin" meaning stop). [11] [8] Myostatin is a protein that inhibits muscle development. This mutation also interferes with fat deposition, resulting in very lean meat. [8] The truncated myostatin gene is unable to ...
Myostatin inhibitors are a class of drugs that work by blocking the effect of myostatin, which inhibits muscle growth. In animal models and limited human studies, myostatin inhibitors have increased muscle size. They are being developed to treat obesity, sarcopenia, muscular dystrophy, and other illnesses.
Mutation and selection A Belgian Blue cow. The defect in the breed's myostatin gene is maintained through linebreeding and is responsible for its accelerated lean muscle growth. This Chihuahua mix and Great Dane shows the wide range of dog breed sizes created using selective breeding.
Knockout mice, where a specific gene was made inoperable by a technique known as gene knockout: the purpose is to study the function of the gene's product or to simulate a human disease Fat mice, prone to obesity due to a carboxypeptidase E deficiency; Strong muscular mice, with a disabled myostatin gene, nicknamed "mighty mice".