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The cell was first discovered by Robert Hooke in 1665 using a microscope. The first cell theory is credited to the work of Theodor Schwann and Matthias Jakob Schleiden in the 1830s. In this theory the internal contents of cells were called protoplasm and described as a jelly-like
At some point a kind of "oily film" was produced that enclosed self-replicating nucleic acids, thereby becoming the first cell. J. D. Bernal named the hypothesis biopoiesis or biopoesis, the process of living matter spontaneously evolving from self-replicating, but lifeless molecules. Haldane further hypothesised that viruses were the ...
Sidney Walter Fox (24 March 1912 – 10 August 1998) was a Los Angeles-born biochemist responsible for discoveries on the origins of biological systems. Fox explored the synthesis of amino acids from inorganic molecules, the synthesis of proteinous amino acids and amino acid polymers called "proteinoids" from inorganic molecules and thermal energy, and created what he thought was the world's ...
Image from his textbook The Cell in Development and Inheritance, second edition, 1900. Edmund Beecher Wilson (October 19, 1856 – March 3, 1939) [2] was a pioneering American zoologist and geneticist. He wrote one of the most influential textbooks in modern biology, The Cell. [3] [4] He discovered the chromosomal XY sex-determination system in ...
1987: Yoshizumi Ishino discovers and describes part of a DNA sequence which later will be called CRISPR. 1989: Thomas Cech discovered that RNA can catalyze chemical reactions, [60] making for one of the most important breakthroughs in molecular genetics, because it elucidates the true function of poorly understood segments of DNA.
In evolutionary biology, the term cellularization (cellularisation) has been used in theories to explain the evolution of cells, for instance in the pre-cell theory, [1] [2] [3] dealing with the evolution of the first cells on this planet, and in the syncytial theory [4] attempting to explain the origin of Metazoa from unicellular organisms.
The study of protein folding began in 1910 with a famous paper by Harriette Chick and C. J. Martin, in which they showed that the flocculation of a protein was composed of two distinct processes: the precipitation of a protein from solution was preceded by another process called denaturation, in which the protein became much less soluble, lost ...
Another common term at that time was the theory of evolution, although "evolution" (in the sense of development as a pure growth process) had a completely different meaning than today. The preformists assumed that the entire organism was preformed in the sperm (animalkulism) or in the egg (ovism or ovulism) and only had to unfold and grow.