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Vitamin B 12 deficiency, also known as cobalamin deficiency, is the medical condition in which the blood and tissue have a lower than normal level of vitamin B 12. [5] Symptoms can vary from none to severe. [1] Mild deficiency may have few or absent symptoms. [1]
Cobalt is an essential element for health in animals in minute amounts as a component of vitamin B 12. A deficiency of cobalt, which is very rare, is also potentially lethal, leading to pernicious anemia. [1] Exposure to cobalt metal dust is most common in the fabrication of tungsten carbide. [2]
Deficiency symptoms in children include developmental delay, regression, irritability, involuntary movements and hypotonia. [34] Vitamin B 12 deficiency is most commonly caused by malabsorption, but can also result from low intake, immune gastritis, low presence of binding proteins, or use of certain medications. [6]
In humans most cobalt is found in Vitamin B12.A cobalt atom is visible in the center in this diagram. Cobalt is essential to the metabolism of all animals.It is a key constituent of cobalamin, also known as vitamin B 12, the primary biological reservoir of cobalt as an ultratrace element.
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The study, which involved 106 peri- and postmenopausal women and was presented at the Endocrine Society’s annual meeting in May, indicates women should self-monitor their vasomotor symptoms and ...
selenium deficiency / selenosis: Cobalt: none NE; NE: Cobalt is available for use by animals only after having been processed into complex molecules (e.g., vitamin B 12) by bacteria. Humans contain only milligrams of cobalt in these cofactors. A deficiency of cobalt leads to pernicious anemia.
Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24]