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This is an example of a scaffold. Scaffolding is a technique used in bioinformatics. It is defined as follows: [1] Link together a non-contiguous series of genomic sequences into a scaffold, consisting of sequences separated by gaps of known length. The sequences that are linked are typically contiguous sequences corresponding to read overlaps.
This example illustrates that one can sometimes increase the N50 length simply by removing some of the shortest contigs or scaffolds from an assembly. If the estimated or known size of the genome from the fictional species A is 500 kbp then the NG50 contig length is 30 kbp because 80 + 70 + 50 + 40 + 30 is greater than 50% of 500.
the dynamic properties of S/MAR-scaffold contacts as derived by haloFISH investigations [5] the fact that during transcription DNA is reeled through RNA-polymerase which itself is a fixed component of the nuclear matrix [6] the fact that certain domain-intrinsic S/MARs require the support of an adjacent transcription factor to become active. [4]
Behavioral epigenetics is the field of study examining the role of epigenetics in shaping animal and human behavior. [1] It seeks to explain how nurture shapes nature, [2] where nature refers to biological heredity [3] and nurture refers to virtually everything that occurs during the life-span (e.g., social-experience, diet and nutrition, and exposure to toxins). [4]
In biology, the chromosome scaffold is the backbone that supports the structure of the chromosomes. It is composed of a group of non-histone proteins that are essential in the structure and maintenance of eukaryotic chromosomes throughout the cell cycle. These scaffold proteins are responsible for the condensation of chromatin during mitosis. [1]
In bioinformatics, sequence assembly refers to aligning and merging fragments from a longer DNA sequence in order to reconstruct the original sequence. [1] This is needed as DNA sequencing technology might not be able to 'read' whole genomes in one go, but rather reads small pieces of between 20 and 30,000 bases, depending on the technology used. [1]
The theory behind cognitive genomics is based on elements of genetics, evolutionary biology, molecular biology, cognitive psychology, behavioral psychology, and neurophysiology. Intelligence is the most extensively studied behavioral trait. [1] In humans, approximately 70% of all genes are expressed in the brain. [2]
A common example of how scaffolds enhance specificity is a scaffold that binds a protein kinase and its substrate, thereby ensuring specific kinase phosphorylation. Additionally, some signaling proteins require multiple interactions for activation and scaffold tethering may be able to convert these interactions into one interaction that results ...