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A myofibroblast is a cell phenotype that was first described as being in a state between a fibroblast and a ... Epithelial to mesenchymal transdifferentiation ...
Fibroblastic and myofibroblastic tumors (FMTs) are tumors which develop from the mesenchymal stem cells which differentiate into fibroblasts (the most common cell type in connective tissue) and/or the myocytes/myoblasts that differentiate into muscle cells.
This change is seen as a transdifferentiation whereby the cells lose their stellate shape and acquire that of myofibroblasts. [8] [6] This state of the stellate cell is the main source of extracellular matrix production in liver injury. [9] This attribute makes it a key factor in the pathophysiology of the liver.
Transdifferentiation, also known as lineage reprogramming, [1] is the process in which one mature somatic cell is transformed into another mature somatic cell without undergoing an intermediate pluripotent state or progenitor cell type. [2] It is a type of metaplasia, which includes all cell fate switches, including the interconversion of stem ...
A cancer-associated fibroblast (CAF) (also known as tumour-associated fibroblast; carcinogenic-associated fibroblast; activated fibroblast) is a cell type within the tumor microenvironment that promotes tumorigenic features by initiating the remodelling of the extracellular matrix or by secreting cytokines.
A list of examples of in vivo transdifferentiation through transfection: [1] mouse hepatocytes → B cells (Pdx1) [2] exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A) [3] nonsensory cells → inner hair cells (Atoh1 and MathI) [4]
The epithelial–mesenchymal transition (EMT) is a process by which epithelial cells lose their cell polarity and cell–cell adhesion, and gain migratory and invasive properties to become mesenchymal stem cells; these are multipotent stromal cells that can differentiate into a variety of cell types.
Thomas Graf (born 28 September 1944) is a biologist at the Centre for Genomic Regulation (CRG) in Barcelona, Spain. He is a pioneer in cell reprogramming, showing that blood cells can be transdifferentiated by transcription factors.